|
One Turn of the Cycle |
|
Acetyl-CoA + 3 NAD+ + FAD + GDP + Pi
+ 3 H2O |
---> |
3 NADH + FADH2 + CoA-SH + GTP + 3 CO2 |
|
|
|
|
|
Acetyl-CoA |
|
|
 |
Oxaloacetate |
 |
Citrate |
 |
|
Malate |
|
|
|
Isocitrate |
|
 |
|
|
|
 |
|
Fumarate |
|
|
|
a-Ketoglutarate |
|
 |
Succinate |
 |
Succinyl-CoA |
 |
|
Gibbs Free Energy Changes
| Rxn# |
Enzyme |
DG°'
(kJ/mol) |
DG
(kJ/mol) |
| 1 |
Citrate synthase |
-32.2 |
|
| 2 |
Aconitase |
+6.3 |
|
| 3 |
Isocitrate dehydrogenase |
-20.9 |
|
| 4 |
a-Ketoglutarate dehydrogenase
complex |
-33.5 |
|
| 5 |
Succinyl-CoA synthetase |
-2.9 |
|
| 6 |
Succinate dehydrogenase |
0.0 |
|
| 7 |
Fumerase |
-3.8 |
|
| 8 |
Malate dehydrogenase |
+29.7 |
|
|
|
