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BIOCHEMISTRY ONLINE
Shikimate Pathway
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CHAPTER 1: LIPIDS
CHAPTER 2: PROTEINS
CHAPTER 3: CARBOHYDRATES
CHAPTER 4 - NUCLEIC ACIDS
CHAPTER 5: BINDING
CHAPTER 6 - TRANSPORT AND KINETICS
CHAPTER 7 - CATALYSIS
CHAPTER 8: OXIDATIVE-PHOSPHORYLATION
CHAPTER 9 - SIGNAL TRANSDUCTION
Chapter 10: METABOLIC PATWAYS
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Overall Reaction for the Pathway

D-Erythrose-4-phosphate + 2  Phosphoenoylpyruvate + NAD+ + NADPH + ATP ---> Chorismate + NADH + NADP+ + ADP + 4 Pi

Erythrose-4-Phosphate Phosphoenoylpyruvate
D-Erythrose-4-Phosphate + Phosphoenoylpyruvate
H2O


Pi
Enzyme Complex
7phospho2dehydro3deoxyarabinoheptonate
7-Phospho-2-dehydro-3-deoxy-D-arabinoheptulosonate
NAD+


NADH, H+, Pi
Co++

3-Dehydroquinate synthase
3dehydroquinate
3-Dehydroquinate



H2O
3-Dehydroquinate dehydratase
3dehydroshikimate
3-Dehydroshikimate
NADPH, H+


NADP+
Shikimate dehydrogenase
shikimate
Shikimate
ATP


ADP
Mg++

Shikimate kinase
3phosphoshikimate
3-Phosphoshikimate
Phosphoenoylpyruvate


Pi
3-phosphoshikimate-1-carboxyvinyl transferase

(EPSP synthase)
3phospho5enoylpyruvylshikimate
3-Phospho-5-enoylpyruvylshikimate



Pi
Chorismate synthase
chorismate
Chorismate

Biochemistry - Where molecules become life...