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Cholesterol Biosynthesis
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CHAPTER 1: LIPIDS
CHAPTER 2: PROTEINS
CHAPTER 3: CARBOHYDRATES
CHAPTER 4 - NUCLEIC ACIDS
CHAPTER 5: BINDING
CHAPTER 6 - TRANSPORT AND KINETICS
CHAPTER 7 - CATALYSIS
CHAPTER 8: OXIDATIVE-PHOSPHORYLATION
CHAPTER 9 - SIGNAL TRANSDUCTION
Chapter 10: METABOLIC PATWAYS
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Overall Reaction for the Pathway

6 Acetyl-CoA + 6 Acetoacetyl-CoA + 14 NADPH + 14 H+ + 5 H2O + 18 ATP + O2 ---> Lanosterol + 14 NADP+ + 12 CoA-S-H + 18 ADP + 6 Pi + 4 PPi + 6 CO2

Acetyl-CoA Acetoacetyl-CoA
Acetyl-CoA + Acetoacetyl-CoA
H2O


CoASH
Hydroxymethyl glutaryl CoA synthase
Hydroxymethylglutaryl CoA
3-Hydroxy-3-methyl-glutaryl CoA
2 NADPH + H+


2 NADP+, CoA-S-H
Hydroxymethyl glutaryl CoA reductase
Mevalonate
Mevalonate
ATP


ADP
Mg++

Mevalonate kinase
Mevalonatephosphate
Mevalonate-5-phosphate
ATP


ADP
Mg++

Phosphomevalonate kinase
Mevalonatepyrophosphate
Mevalonate-5-pyrophosphate
ATP


ADP, Pi, CO2
Diphosphomevalonate decarboxylase
Isopentenyl-PP
D3-Isopentenyl pyrophosphate
Mg++

Isopentenyldiphosphate isomerase
Dimethylallyl-PP
Dimethylallyl pyrophosphate
D3-Isopentenyl pyrophosphate


PPi
Dimethylallyl-trans-transferase
Geranyl-PP
Geranyl pyrophosphate
D3-Isopentenyl pyrophosphate


PPi
Geranyl-trans-transferase
Farnesyl-PP
Farnesyl pyrophosphate
Farnesyl pyrophosphate


Farnesyl-PP farnesyl transferase
NADPH, H+


NADP+
Squalene
Squalene
Squalene Monooxygenase O2


H2O
NADPH, H+


NADP+
Squalene epoxide
(S)-Squalene-2,3-epoxide
Lanesterol synthase
Lanosterol
Lanosterol

Biochemistry - Where molecules become life...