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BIOCHEMISTRY ONLINE
D: PROTEOMICS
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CHAPTER 1: LIPIDS
CHAPTER 2: PROTEINS
CHAPTER 3: CARBOHYDRATES
CHAPTER 4 - NUCLEIC ACIDS
CHAPTER 5: BINDING
CHAPTER 6 - TRANSPORT AND KINETICS
CHAPTER 7 - CATALYSIS
CHAPTER 8: OXIDATIVE-PHOSPHORYLATION
CHAPTER 9 - SIGNAL TRANSDUCTION
Chapter 10: METABOLIC PATWAYS
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The human genome project was a cinch compared to the complexity of understanding the extent and type of gene expression in a given cell, the proteins produced, and how these proteins interact to create biological function.   The emerging field of proteomics, which will study these types of questions, will revolutionize our understanding of normal and disease processes in cells.  Richard Burgess, UW Madison, includes the following activities in proteomics: (C&E New, July 31, 2000, pg 31)

  • "Transcriptional profiling to determine which genes are transcribed into RNA in particular cell type, developmental stage, or diseased state".
  • High-throughput expression and purification of proteins
  • Protein profiling, using 2D gel electrophoresis and mass spectrometry to study proteins expressed in a cell
  • Protein-protein interaction studies to see which proteins function together using the yeast two hybrid method
  • Pathway analysis to understand signal transduction and other complex cell processes
  • Large scale protein folding and 3D structure studies
  • Bioinformatics analysis of proteomic data
  • More latter.

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Biochemistry - Where molecules become life...